Prevalence of bacterial coinfection and patterns of antibiotics prescribing in patients with COVID-19 : a systematic review and meta-analysis

Alshaikh, Faisal Salman and Sindi, Oula Nawaf and Godman, Brian and Seaton, R Andrew and Kurdi, Amanj (2022) Prevalence of bacterial coinfection and patterns of antibiotics prescribing in patients with COVID-19 : a systematic review and meta-analysis. PLoS ONE, 17 (8). e0272375. ISSN 1932-6203 (https://doi.org/10.1371/journal.pone.0272375)

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Abstract

Background: Evidence around prevalence of bacterial coinfection and pattern of antibiotic use in COVID-19 is controversial although high prevalence rates of bacterial coinfection have been reported in previous similar global viral respiratory pandemics. Early data on the prevalence of antibiotic prescribing in COVID-19 indicates conflicting low and high prevalence of antibiotic prescribing which challenges antimicrobial stewardship programmes and increases risk of antimicrobial resistance (AMR). Aim: To determine current prevalence of bacterial coinfection and antibiotic prescribing in COVID-19 patients Data Source: OVID MEDLINE, OVID EMBASE, Cochrane and MedRxiv between January 2020 and June 2021. Study Eligibility: English language studies of laboratory-confirmed COVID-19 patients which reported (a) prevalence of bacterial coinfection and/or (b) prevalence of antibiotic prescribing with no restrictions to study designs or healthcare setting Participants: Adults (aged ≥ 18 years) with RT-PCR confirmed diagnosis of COVID-19, regardless of study setting. Methods: Systematic review and meta-analysis. Proportion (prevalence) data was pooled using random effects meta-analysis approach; and stratified based on region and study design. Results: A total of 1058 studies were screened, of which 22, hospital-based studies were eligible, compromising 76,176 of COVID-19 patients. Pooled estimates for the prevalence of bacterial co-infection and antibiotic use were 5.62% (95% CI 2.26 – 10.31) and 61.77% (CI 50.95 – 70.90), respectively. Sub-group analysis by region demonstrated that bacterial co-infection was more prevalent in North American studies (7.89%, 95% CI 3.30-14.18). Conclusion: Prevalence of bacterial coinfection in COVID-19 is low, yet prevalence of antibiotic prescribing is high, indicating the need for targeted COVID-19 antimicrobial stewardship initiatives to reduce the global threat of AMR.

ORCID iDs

Alshaikh, Faisal Salman, Sindi, Oula Nawaf, Godman, Brian, Seaton, R Andrew and Kurdi, Amanj ORCID logoORCID: https://orcid.org/0000-0001-5036-1988;
CORE (COnnecting REpositories)