3D-printed high-resolution microchannels for contrast enhanced ultrasound research

Domingo-Roca, Roger and Gilmour, Lauren and Asciak, Lisa and Sarrigiannidis, Stylianos and Dobre, Oana and Salmeron-Sanchez, Manuel and Sandison, Mairi and O'Leary, Richard and Jackson-Camargo, Joseph and Mulvana, Helen; (2022) 3D-printed high-resolution microchannels for contrast enhanced ultrasound research. In: 2021 IEEE International Ultrasonics Symposium (IUS). 2021 IEEE Ultrasonics Symposium (IUS), 2021-Janu . IEEE, CHN, pp. 1-4. ISBN 9781665403559 (https://doi.org/10.1109/ius52206.2021.9763442)

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Abstract

Systemically circulating microbubbles are used as contrast agents to aid both drug targeting and delivery using ultrasound. Exploiting their acoustic behaviour in small diameter vessels is critical for both applications, but the highly controlled experiments required to support this are not possible in vivo and challenging in vitro. Experimental platforms with small diameter channels (below 200 microns) are not readily available nor able to represent vascular geometries, leaving the existence and extent of microbubble-microvessel interactions incompletely defined. In this work we present a 3D-printed microchannel platform using tissue-mimicking hydrogels featuring radii down to 75 microns. We demonstrate application to study microbubble behaviour via acoustic backscatter under controlled environments in physiologically-relevant conditions.

ORCID iDs

Domingo-Roca, Roger ORCID logoORCID: https://orcid.org/0000-0001-6080-0083, Gilmour, Lauren, Asciak, Lisa ORCID logoORCID: https://orcid.org/0009-0008-8285-198X, Sarrigiannidis, Stylianos, Dobre, Oana, Salmeron-Sanchez, Manuel, Sandison, Mairi ORCID logoORCID: https://orcid.org/0000-0003-1021-1461, O'Leary, Richard ORCID logoORCID: https://orcid.org/0000-0002-4092-2101, Jackson-Camargo, Joseph and Mulvana, Helen ORCID logoORCID: https://orcid.org/0000-0002-5058-0299;
  • Item type:Book Section
    ID code:81049
    Dates:
    Date
    Event
    27 April 2022
    Published
    7 June 2021
    Accepted
    Notes:This article was mistakenly omitted from the original submission to IEEE Xplore. It is now included as part of the conference record. © 2022 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting /republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works
    Subjects:Technology > Electrical engineering. Electronics Nuclear engineering
    Department:Faculty of Engineering > Biomedical Engineering
    Faculty of Engineering > Electronic and Electrical Engineering
    Depositing user: Pure Administrator
    Date deposited:13 Jun 2022 09:27
    Last modified:17 Nov 2024 01:32
    URI:https://strathprints.strath.ac.uk/id/eprint/81049
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