Multisystem inflammatory syndrome of a neonate from a COVID-19-infected mother : a case report

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Malek, Abdul and Khadga, Mukesh and Zahid, Nurnobi and Mojib, Sanjida and Debnath, Reena and Khan, Seela and Haque, Mainul and Godman, Brian and Islam, Salequl (2022) Multisystem inflammatory syndrome of a neonate from a COVID-19-infected mother : a case report. Cureus, 14 (3). e23046. (https://doi.org/10.7759/cureus.23046)

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Abstract

In neonates, the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 – COVID-19) is lower. There is the potential for vertical transmission of SARS-CoV-2. To date, only a few reports suggest this possibility. Neonates usually have mild symptoms, but some develop multisystem involvement, which is a concern. COVID-19 infections have been reported both in pregnant women and their neonates. However, the evidence of vertical or horizontal transmission modes has not been fully established. We recorded a case study where a 33-year-old mother was tested positive for COVID-19 infection by RT-PCR during her 27th week of gestation and needed ventilator support for her respiratory distress at that time for 11 days. Subsequently, she gave birth to a female baby at the 35th week via a lower uterine segment cesarean section. The neonate manifested a severe multisystem inflammatory syndrome associated with her possible COVID-19 infection. Sharing her uncommon clinical presentation, immunological syndrome, and disease outcome are noteworthy for similar unforeseen pediatric case management to help guide future investigations and care

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