Organic bioelectronics for in vitro systems

Pitsalidis, Charalampos and Pappa, Anna-Maria and Boys, Alexander J. and Fu, Ying and Moysidou, Chrysanthi-Maria and van Niekerk, Douglas and Saez, Janire and Savva, Achilleas and Iandolo, Donata and Owens, Róisín M. (2022) Organic bioelectronics for in vitro systems. Chemical Reviews, 122 (4). pp. 4700-4790. ISSN 0009-2665 (https://doi.org/10.1021/acs.chemrev.1c00539)

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Abstract

Bioelectronics have made strides in improving clinical diagnostics and precision medicine. The potential of bioelectronics for bidirectional interfacing with biology through continuous, label-free monitoring on one side and precise control of biological activity on the other has extended their application scope to in vitro systems. The advent of microfluidics and the considerable advances in reliability and complexity of in vitro models promise to eventually significantly reduce or replace animal studies, currently the gold standard in drug discovery and toxicology testing. Bioelectronics are anticipated to play a major role in this transition offering a much needed technology to push forward the drug discovery paradigm. Organic electronic materials, notably conjugated polymers, having demonstrated technological maturity in fields such as solar cells and light emitting diodes given their outstanding characteristics and versatility in processing, are the obvious route forward for bioelectronics due to their biomimetic nature, among other merits. This review highlights the advances in conjugated polymers for interfacing with biological tissue in vitro, aiming ultimately to develop next generation in vitro systems. We showcase in vitro interfacing across multiple length scales, involving biological models of varying complexity, from cell components to complex 3D cell cultures. The state of the art, the possibilities, and the challenges of conjugated polymers toward clinical translation of in vitro systems are also discussed throughout.

ORCID iDs

Pitsalidis, Charalampos, Pappa, Anna-Maria, Boys, Alexander J., Fu, Ying ORCID logoORCID: https://orcid.org/0000-0002-8196-6493, Moysidou, Chrysanthi-Maria, van Niekerk, Douglas, Saez, Janire, Savva, Achilleas, Iandolo, Donata and Owens, Róisín M.;
  • Item type:Article
    ID code:79142
    Dates:
    Date
    Event
    23 February 2022
    Published
    15 December 2021
    Published Online
    11 December 2021
    Accepted
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:14 Jan 2022 11:57
    Last modified:17 Nov 2024 13:55
    URI:https://strathprints.strath.ac.uk/id/eprint/79142
CORE (COnnecting REpositories)