Challenges to recruitment of participants with MCI in a multicentric neuropsychological study

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Brambillaa, Michela and Parra, Mario A and Della Sala, Sergio and Alemanno, Federica and Pomati, Simone (2020) Challenges to recruitment of participants with MCI in a multicentric neuropsychological study. Aging Clinical and Experimental Research. ISSN 1594-0667 (https://doi.org/10.1007/s40520-020-01729-3)

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Abstract

Background: Data on recruitment of Mild Cognitive Impairment (MCI) samples are seldom reported and this issue can be an important source of research waste. Aim: To describe the recruitment challenges and reasons for non-eligibility faced during a bi-centre clinical study assessing the predictive value of a neuropsychological battery of the progression to dementia. Methods: Potential MCI participants were identified from databases of the two memory clinics based in Milan (Italy) and invited to the screening assessment. Results: About 50% of the cases initially identified were ineligible according to inclusion/exclusion criteria and the two sites took 22 months to recruit the planned 150 people. The main reasons for non-eligibility were the MMSE score (41%), age (14%), presence of cerebrovascular disorders (9%), perceptual deficits (6%), neurological (6%) or psychiatric (4%) comorbidities and low education (5%). Conclusion: Awareness of the reasons for exclusion and of the time needed to recruit the planned sample would provide hints for the planning of future studies on MCI.

ORCID iDs

Brambillaa, Michela, Parra, Mario A ORCID logoORCID: https://orcid.org/0000-0002-2412-648X, Della Sala, Sergio, Alemanno, Federica and Pomati, Simone;
CORE (COnnecting REpositories)