Stereoselective remote functionalization via palladium catalyzed redox-relay Heck methodologies

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Bonfield, Holly E. and Valette, Damien and Lindsay, David M. and Reid, Marc (2021) Stereoselective remote functionalization via palladium catalyzed redox-relay Heck methodologies. Chemistry - A European Journal, 27 (1). pp. 158-174. ISSN 1521-3765 (https://doi.org/10.1002/chem.202002849)

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Abstract

Exploration of novel, three-dimensional chemical space is of growing interest in the drug discovery community and with this comes the challenge for synthetic chemists to devise new stereoselective methods to introduce chirality in a rapid and efficient manner. This Minireview provides a timely summary of the development of palladium-catalyzed asymmetric redox-relay Heck-type processes. These reactions represent an important class of transformation for the selective introduction of remote stereocenters, and have risen to prominence over the past decade. Within this Minireview, the vast scope of these transformations will be showcased, alongside applications to pharmaceutically relevant chiral building blocks and drug substances. To complement this overview, a mechanistic summary and discussion of the current limitations of the transformation are presented, followed by an outlook on future areas of investigation.

ORCID iDs

Bonfield, Holly E., Valette, Damien, Lindsay, David M. ORCID logoORCID: https://orcid.org/0000-0003-4498-5094 and Reid, Marc ORCID logoORCID: https://orcid.org/0000-0003-4394-3132;
  • Item type:Article
    ID code:73551
    Dates:
    Date
    Event
    4 January 2021
    Published
    3 August 2020
    Published Online
    31 July 2020
    Accepted
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:11 Aug 2020 14:28
    Last modified:12 Dec 2024 10:11
    URI:https://strathprints.strath.ac.uk/id/eprint/73551
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