In-silico characterisation of the Kirkstall QV900 in-vitro system for advanced cell culture

Tools

McGinty, Sean and Hyndman, Lauren and Mottram, Nigel and McKee, Sean and Webb, Steven; Nithiarasu, Perumal and Robertson, Anne M., eds. (2017) In-silico characterisation of the Kirkstall QV900 in-vitro system for advanced cell culture. In: CMBE17. Zeta Computational Resources Ltd., USA, pp. 1174-1177. ISBN 9780956291448

[thumbnail of McGinty-etal-CMBE2017-In-silico-characterisation-of-the-Kirkstall-QV900-in-vitro-system]
Preview
 Text. Filename: McGinty_etal_CMBE2017_In_silico_characterisation_of_the_Kirkstall_QV900_in_vitro_system.pdf
Accepted Author Manuscript
Download (405kB)| Preview

Abstract

We have developed an in-silico model of the Kirkstall Quasi-Vivo QV900 cell culture system. The QV900 consists of a series of connected sealed chambers, within which cells can be cultured in a low shear stress flow environment. By modelling fluid flow and oxygen transport within the chambers, we have been able to simulate flow patterns and shear stress/oxygen levels experienced by the cells, and we have demonstrated that physiologically relevant oxygen concentration gradients can be achieved by configuring connected chambers in a particular way.

ORCID iDs

McGinty, Sean, Hyndman, Lauren, Mottram, Nigel ORCID logoORCID: https://orcid.org/0000-0002-7265-0059, McKee, Sean and Webb, Steven; Nithiarasu, Perumal and Robertson, Anne M.
CORE (COnnecting REpositories)