Increased risk of HPV-associated genital cancers in men and women as a consequence of pre-invasive disease

Pan, Jiafeng and Kavanagh, Kimberley and Cuschieri, Kate and Pollock, Kevin G and Gilbert, Duncan C and Millan, David and Bell, Sarah and Graham, Sheila V and Williams, Alistair R W and Cruickshank, Margaret E and Palmer, Tim and Wakeham, Katie (2019) Increased risk of HPV-associated genital cancers in men and women as a consequence of pre-invasive disease. International Journal of Cancer, 145 (2). pp. 427-434. ISSN 0020-7136 (https://doi.org/10.1002/ijc.32126)

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Abstract

To assess the excess risk of HPV-associated cancer (HPVaC) in two at-risk groups—women with a previous diagnosis of high grade cervical intraepithelial neoplasia (CIN3) and both men and women treated for non-cervical pre-invasive anogenital disease. All CIN3 cases diagnosed in 1989–2015 in Scotland were extracted from the Scottish cancer registry (SMR06). All cases of pre-invasive penile, anal, vulval, and vaginal disease diagnosed in 1990–2015 were identified within the NHS pathology databases in the two largest NHS health boards in Scotland. Both were linked to SMR06 to extract subsequent incidence of HPVaC following the diagnosis of CIN3 or pre-invasive disease. Standardised incidence ratios were calculated for the risk of acquiring HPVaC for the two at-risk groups compared to the general Scottish population. Among 69,714 females in Scotland diagnosed with CIN3 (890,360.9 person-years), 179 developed non-cervical HPVaC. CIN3 cases were at 3.2-fold (95% CI: 2.7 to 3.7) increased risk of developing non-cervical HPVaC, compared to the general female population. Among 1,235 patients diagnosed with non-cervical pre-invasive disease (9,667.4 person-years), 47 developed HPVaC. Individuals with non-cervical pre-invasive disease had a substantially increased risk of developing HPVaC - 15.5-fold (95% CI: 11.1 to 21.1) increased risk for females and 28-fold (11.3 to 57.7) increased risk for males. We report a significant additional risk of HPV-associated cancer in those have been diagnosed with pre-invasive HPV-associated lesions including but not confined to the cervix. Uncovering the natural history of pre-invasive disease has potential for determining screening, prevention and treatment.

ORCID iDs

Pan, Jiafeng ORCID logoORCID: https://orcid.org/0000-0001-5993-3209, Kavanagh, Kimberley ORCID logoORCID: https://orcid.org/0000-0002-2679-5409, Cuschieri, Kate, Pollock, Kevin G, Gilbert, Duncan C, Millan, David, Bell, Sarah, Graham, Sheila V, Williams, Alistair R W, Cruickshank, Margaret E, Palmer, Tim and Wakeham, Katie;
  • Item type:Article
    ID code:66697
    Dates:
    Date
    Event
    15 July 2019
    Published
    16 January 2019
    Published Online
    16 November 2018
    Accepted
    Notes:This is the pre-peer reviewed version of the following article: Pan, J, Kavanagh, K, Cuschieri, K, Pollock, KG, Gilbert, DC, Millan, D, Bell, S, Graham, SV, Williams, ARW, Cruickshank, ME, Palmer, T & Wakeham, K 2019, 'Increased risk of HPV-associated genital cancers in men and women as a consequence of pre-invasive disease' International Journal of Cancer., which has been published in final form at https://doi.org/10.1002/ijc.32126. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
    Subjects:Medicine > Internal medicine > Neoplasms. Tumors. Oncology (including Cancer)
    Department:Faculty of Science > Mathematics and Statistics
    Depositing user: Pure Administrator
    Date deposited:23 Jan 2019 12:41
    Last modified:11 Nov 2024 12:12
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/66697
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