A mechanistic model of high dose irradiation damage

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Siam, F.M. and Grinfeld, M. and Bahar, A. and Rahman, H.A. and Ahmad, H. and Johar, F. (2018) A mechanistic model of high dose irradiation damage. Mathematics and Computers in Simulation, 151. pp. 156-168. ISSN 0378-4754 (https://doi.org/10.1016/j.matcom.2016.02.007)

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Abstract

The main goal of our study is to develop a realistic mechanistic model of the effect of ionizing radiation on DNA in mammalian cells. We consider a population of cells structured by the number of DNA double strand breaks due to radiation. Using the system of linear differential equation, the model describes the evolution of the irradiated population of cells in time. The work is in three parts. First, we consider the effect of a single dose of radiation, while in the second part we work on the model parameter estimation using Nelder–Mead simplex algorithm which allows us to relate the clinically useful parameters of the LQ relation to aspects of cellular activity that can be manipulated experimentally. In the third part, we deal with cell killing effects of fractioned doses of radiation. Using MATLAB, we observed the cell survival fractions can be well approximated by the Linear–Quadratic relation and also show fewer cell will die if the dose is fractionated in two or more fractions

  • Item type:Article
    ID code:66472
    Dates:
    Date
    Event
    30 September 2018
    Published
    19 March 2016
    Published Online
    21 February 2016
    Accepted
    Subjects:Science > Mathematics
    Department:Faculty of Science > Mathematics and Statistics
    Depositing user: Pure Administrator
    Date deposited:08 Jan 2019 11:38
    Last modified:11 Nov 2024 12:11
    URI:https://strathprints.strath.ac.uk/id/eprint/66472
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