Tetrazine‐responsive self‐immolative linkers

Neumann, Kevin and Jain, Sarthak and Gambardella, Alessia and Walker, Sarah E. and Valero, Elsa and Lilienkampf, Annamaria and Bradley, Mark (2017) Tetrazine‐responsive self‐immolative linkers. Chembiochem, 18 (1). pp. 91-95. ISSN 1439-4227 (https://doi.org/10.1002/cbic.201600560)

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Abstract

Molecules that undergo activation or modulation following the addition of benign external small‐molecule chemical stimuli have numerous applications. Here, we report the highly efficient “decaging” of a variety of moieties by activation of a “self‐immolative” linker, by application of water‐soluble and stable tetrazine, including the controlled delivery of doxorubicin in a cellular context.

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• Item metadata

  Item type:	Article
  ID code:	64803
  Dates:	Date Event 3 January 2017 Published 14 November 2016 Published Online 24 October 2016 Accepted
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	19 Jul 2018 14:30
  Last modified:	18 Nov 2024 01:11
  Related URLs:	Related item
  URI:	https://strathprints.strath.ac.uk/id/eprint/64803