An integrative approach to decipher the chemical antagonism between the competing endophytes paraconiothyrium variabile and Bacillus subtilis

Vallet, Marine and Vanbellingen, Quentin P. and Fu, Tingting and Le Caer, Jean-Pierre and Della-Negra, Serge and Touboul, David and Duncan, Katherine R. and Nay, Bastien and Brunelle, Alain and Prado, Soizic (2017) An integrative approach to decipher the chemical antagonism between the competing endophytes paraconiothyrium variabile and Bacillus subtilis. Journal of Natural Products, 80 (11). 2863–2873. ISSN 0163-3864 (https://doi.org/10.1021/acs.jnatprod.6b01185)

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Abstract

An integrative approach combining traditional natural products chemistry, molecular networking, and mass spectrometry imaging has been undertaken to decipher the molecular dialogue between the fungus Paraconiothyrium variabile and the bacterium Bacillus subtilis, which were isolated as endophytes from the conifer Cephalotaxus harringtonia and are characterized by a strong and mutual antibiosis. From this study, we highlight that bacterial surfactins and a fungal tetronic acid are involved in such competition and that the fungus is able to hydrolyze surfactins to fight against the bacterial partner.

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