A simple hand-held magnet array for efficient and reproducible SABRE hyperpolarisation using manual sample shaking

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Richardson, Peter M. and Jackson, Scott and Parrott, Andrew and Nordon, Alison and Duckett, Simon B. and Halse, Meghan E. (2018) A simple hand-held magnet array for efficient and reproducible SABRE hyperpolarisation using manual sample shaking. Magnetic Resonance in Chemistry, 56 (7). pp. 641-650. ISSN 0749-1581 (https://doi.org/10.1002/mrc.4687)

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Abstract

Signal amplification by reversible exchange (SABRE) is a hyperpolarisation technique that catalytically transfers nuclear polarisation from parahydrogen, the singlet nuclear isomer of H2, to a substrate in solution. The SABRE exchange reaction is carried out in a polarisation transfer field (PTF) of tens of gauss before transfer to a stronger magnetic field for NMR detection. In the simplest implementation, polarisation transfer is achieved by shaking the sample in the stray field of a superconducting NMR magnet. While convenient, this method suffers from limited reproducibility and cannot be used with NMR spectrometers that do not have appreciable stray fields, such as benchtop instruments. Here we use a simple hand-held permanent magnet array to provide the necessary PTF during sample shaking. We find that the use of this array provides a 25% increase in SABRE enhancement over the stray field approach, while also providing improved reproducibility. Arrays with a range of PTFs were tested and the PTF-dependent SABRE enhancements were found to be in excellent agreement with comparable experiments carried out using an automated flow system where an electromagnet is used to generate the PTF. We anticipate that this approach will improve the efficiency and reproducibility of SABRE experiments carried out using manual shaking and will be particularly useful for benchtop NMR, where a suitable stray field is not readily accessible. The ability to construct arrays with a range of PTFs will also enable the rapid optimisation of SABRE enhancement as function of PTF for new substrate and catalyst systems.

ORCID iDs

Richardson, Peter M., Jackson, Scott, Parrott, Andrew ORCID logoORCID: https://orcid.org/0000-0002-4598-2736, Nordon, Alison ORCID logoORCID: https://orcid.org/0000-0001-6553-8993, Duckett, Simon B. and Halse, Meghan E.;
CORE (COnnecting REpositories)