Synthesis of poly(acrylonitrile-co-divinylbenzene-co-vinylbenzyl chloride)-derived hypercrosslinked polymer microspheres and a preliminary evaluation of their potential for the solid-phase capture of pharmaceuticals

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Subri, Nur Nida Syamimi and Cormack, Peter A. G. and Jamil, Siti Nurul Ain Md. and Abdullah, Luqman Chuah and Daik, Rusli (2018) Synthesis of poly(acrylonitrile-co-divinylbenzene-co-vinylbenzyl chloride)-derived hypercrosslinked polymer microspheres and a preliminary evaluation of their potential for the solid-phase capture of pharmaceuticals. Journal of Applied Polymer Science, 135 (2). 45677. ISSN 0021-8995 (https://doi.org/10.1002/app.45677)

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Abstract

Poly[acrylonitrile (AN)-co-divinylbenzene (DVB)-co-vinylbenzyl chloride (VBC)] terpolymers were synthesized by precipitation polymerization in the form of porous polymer microspheres. The poly(AN-co-DVB-co-VBC) polymers were then hypercrosslinked, via a Friedel-Crafts reaction with FeCl3 in nitrobenzene, to provide a significant uplift in the specific surface areas of the polymers. FT-IR spectra of the hypercrosslinked poly(AN-co-DVB-co-VBC)s showed that the chloromethyl groups derived from VBC were consumed by the Friedel-Crafts reactions, which was consistent with successful hypercrosslinking. Hypercrosslinking installed a number of new, small pores into the polymers, as evidenced by a dramatic increase in the specific surface areas upon hypercrosslinking (from ∼530 to 1080 m2 g−1). The hypercrosslinked polymers are very interesting for a range of applications, not least of all for solid-phase extraction (SPE) work, where the convenient physical form of the polymers (beaded format), their low mean particle diameters, and narrow particle size distributions, as well as their high specific surface areas and polar character (arising from the AN residues), make them attractive candidates as SPE sorbents. In this regard, in a preliminary study one of the hypercrosslinked polymers was utilized as an SPE sorbent for the capture of the polar pharmaceutical diclofenac from a polar environment.

ORCID iDs

Subri, Nur Nida Syamimi, Cormack, Peter A. G. ORCID logoORCID: https://orcid.org/0000-0002-3390-8176, Jamil, Siti Nurul Ain Md., Abdullah, Luqman Chuah and Daik, Rusli;
  • Item type:Article
    ID code:61711
    Dates:
    Date
    Event
    10 January 2018
    Published
    26 August 2017
    Published Online
    5 August 2017
    Accepted
    Notes:This is the peer reviewed version of the following article: Subri, N. N. S., Cormack, P. A. G., Md. Jamil, S. N. A., Abdullah, L. C. and Daik, R. (2017), Synthesis of poly(acrylonitrile-co-divinylbenzene-co-vinylbenzyl chloride)-derived hypercrosslinked polymer microspheres and a preliminary evaluation of their potential for the solid-phase capture of pharmaceuticals. J. Appl. Polym. Sci., 45677, which has been published in final form at https://doi.org/10.1002/app.45677. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:05 Sep 2017 11:12
    Last modified:03 Dec 2024 01:16
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/61711
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