Development of a solid dosage platform for the oral delivery of bilayer vesicles

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Wilkhu, Jitinder S. and McNeil, Sarah E. and Anderson, David E. and Kirchmeier, Marc and Perrie, Yvonne (2017) Development of a solid dosage platform for the oral delivery of bilayer vesicles. European Journal of Pharmaceutical Sciences, 108. pp. 71-77. ISSN 0928-0987 (https://doi.org/10.1016/j.ejps.2017.06.014)

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Abstract

Within this work, we develop vesicles incorporating sub-unit antigens as solid dosage forms suitable for the oral delivery of vaccines. Using a combination of trehalose, dextran and mannitol, freeze-dried oral disintegrating tablets were formed which upon rehydration release bilayer vesicles incorporating antigen. Initial studies focused on the optimisation of the freeze-dry cycle and subsequently excipient content was optimised by testing tablet hardness, disintegration time and moisture content. The use of 10 % mannitol and 10 % dextran produced durable tablets which offered strong resistance to mechanical damage yet appropriate disintegration times and dispersed to release niosomes-entrapping antigen. From these studies, we have formulated a bilayer vesicle vaccine delivery system as rapid disintegrating tablets and capsules.

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