HPV status and favorable outcome in vulvar squamous cancer

Wakeham, Katie and Kavanagh, Kim and Cuschieri, Kate and Millan, David and Pollock, Kevin G and Bell, Sarah and Burton, Kevin and Reed, Nick and Graham, Sheila V (2017) HPV status and favorable outcome in vulvar squamous cancer. International Journal of Cancer, 140 (5). pp. 1134-1146. ISSN 0020-7136 (https://doi.org/10.1002/ijc.30523)

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Abstract

It is universally accepted that high-risk human papillomavirus (HR-HPV) is the cause of cervical dysplasia and cancer. More recently it has been shown that HPV is also a marker of clinical outcome in oropharyngeal cancer. However, contemporary information is lacking on both the prevalence of HPV infection in vulvar cancer (VSCC), its precursor lesion, vulvar intraepithelial neoplasia (VIN) and the influence of HPV-status on the prognosis of this malignancy. We have conducted a detailed population-based study to examine rates of progression of VIN to VSCC, type-specific HPV prevalence in vulvar disease and the influence of HPV status on clinical outcome in VSCC. We observed that the age at which women are diagnosed with VSCC is falling and there is a significant time gap between first diagnosis of VIN and progression to invasive disease. HR-HPV infection was detected in 87% (97/112) cases of VIN and 52% cases (32/62) of VSCC. The presence of HR-HPV in squamous intraepithelial lesion was associated with lower rates of progression to invasive cancer (hazard ratio, 0.22, p=0.001). In the adjusted analysis, HR-HPV was associated with improved progression-free survival of VSCC compared to those with HPV negative tumours (hazard ratio, 0.32, p=0.02).

ORCID iDs

Wakeham, Katie, Kavanagh, Kim ORCID logoORCID: https://orcid.org/0000-0002-2679-5409, Cuschieri, Kate, Millan, David, Pollock, Kevin G, Bell, Sarah, Burton, Kevin, Reed, Nick and Graham, Sheila V;
  • Item type:Article
    ID code:58603
    Dates:
    Date
    Event
    1 March 2017
    Published
    16 November 2016
    Published Online
    7 October 2016
    Accepted
    Notes:© 2016 UICC Wakeham, K., Kavanagh, K., Cuschieri, K., Millan, D., Pollock, K.G., Bell, S., Burton, K., Reed, N.S. and Graham, S.V. (2017), HPV status and favourable outcome in vulvar squamous cancer. Int. J. Cancer, 140: 1134-1146. https://doi.org/10.1002/ijc.30523
    Subjects:Medicine > Internal medicine > Neoplasms. Tumors. Oncology (including Cancer)
    Department:Faculty of Science > Mathematics and Statistics
    Depositing user: Pure Administrator
    Date deposited:11 Nov 2016 09:53
    Last modified:11 Nov 2024 11:33
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/58603
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