Tissue quality assessment using a novel direct elasticity assessment device (the e-finger) : a cadaveric study of prostatectomy dissection

Good, Daniel W. and Khan, Ashfaq and Hammer, Steven and Scanlan, Paul and Shu, Wenmiao and Phipps, Simon and Parson, Simon H. and Stewart, Grant D. and Reuben, Robert and McNeill, S. Alan (2014) Tissue quality assessment using a novel direct elasticity assessment device (the e-finger) : a cadaveric study of prostatectomy dissection. PLOS One, 9 (11). 112872. ISSN 1932-6203 (https://doi.org/10.1371/journal.pone.0112872)

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Abstract

Introduction Minimally invasive radical prostatectomy (RP) (robotic and laparoscopic), have brought improvements in the outcomes of RP due to improved views and increased degrees of freedom of surgical devices. Robotic and laparoscopic surgeries do not incorporate haptic feedback, which may result in complications secondary to inadequate tissue dissection (causing positive surgical margins, rhabdosphincter damage, etc). We developed a micro-engineered device (6 mm2 sized) [E-finger]) capable of quantitative elasticity assessment, with amplitude ratio, mean ratio and phase lag representing this. The aim was to assess the utility of the device in differentiating peri-prostatic tissue types in order to guide prostate dissection. Material and Methods Two embalmed and 2 fresh frozen cadavers were used in the study. Baseline elasticity values were assessed in bladder, prostate and rhabdosphincter of pre-dissected embalmed cadavers using the micro-engineered device. A measurement grid was created to span from the bladder, across the prostate and onto the rhabdosphincter of fresh frozen cadavers to enable a systematic quantitative elasticity assessment of the entire area by 2 independent assessors. Tissue was sectioned along each row of elasticity measurement points, and stained with haematoxylin and eosin (H&E). Image analysis was performed with Image Pro Premier to determine the histology at each measurement point. Results Statistically significant differences in elasticity were identified between bladder, prostate and sphincter in both embalmed and fresh frozen cadavers (p = <0.001). Intra-class correlation (ICC) reliability tests showed good reliability (average ICC = 0.851). Sensitivity and specificity for tissue identification was 77% and 70% respectively to a resolution of 6 mm2. Conclusions This cadaveric study has evaluated the ability of our elasticity assessment device to differentiate bladder, prostate and rhabdosphincter to a resolution of 6 mm2. The results provide useful data for which to continue to examine the use of elasticity assessment devices for tissue quality assessment with the aim of giving haptic feedback to surgeons performing complex surgery.

ORCID iDs

Good, Daniel W., Khan, Ashfaq, Hammer, Steven, Scanlan, Paul, Shu, Wenmiao ORCID logoORCID: https://orcid.org/0000-0002-1220-361X, Phipps, Simon, Parson, Simon H., Stewart, Grant D., Reuben, Robert and McNeill, S. Alan;
CORE (COnnecting REpositories)