MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

Kalafatovic, Daniela and Nobis, Max and Javid, Nadeem and Frederix, Pim W. J. M. and Anderson, Kurt I. and Saunders, Brian R. and Ulijn, Rein V. (2015) MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin. Biomaterials Science, 3 (2). pp. 246-249. ISSN 2047-4830 (https://doi.org/10.1039/c4bm00297k)

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Abstract

Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.

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• Item metadata

  Item type:	Article
  ID code:	54049
  Dates:	Date Event 20 February 2015 Published 28 October 2014 Published Online 9 October 2014 Accepted
  Subjects:	Medicine > Pharmacy and materia medica
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Faculty of Science > Pure and Applied Chemistry Technology and Innovation Centre > Bionanotechnology
  Depositing user:	Pure Administrator
  Date deposited:	24 Aug 2015 14:22
  Last modified:	14 Apr 2024 00:32
  URI:	https://strathprints.strath.ac.uk/id/eprint/54049