Hardness and density distributions of pharmaceutical tablets measured by terahertz pulsed imaging

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May, Robert K. and Su, Ke and Han, Lianghao and Zhong, Shuncong and Elliott, James A. and Gladden, Lynn F. and Evans, Mike and Shen, Yaochun and Zeitler, J. Axel (2013) Hardness and density distributions of pharmaceutical tablets measured by terahertz pulsed imaging. Journal of Pharmaceutical Sciences, 102 (7). pp. 2179-2186. ISSN 0022-3549 (https://doi.org/10.1002/jps.23560)

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Abstract

We present terahertz pulsed imaging (TPI) as a novel tool to quantify the hardness and surface density distribution of pharmaceutical tablets. Good agreement between the surface refractive index (SRI) measured by TPI and the crushing force measured from diametral compression tests was found using a set of tablets that were compacted at various compression forces. We also found a strong correlation between TPI results and tablet bulk density, and how these relate to tablet hardness. Numerical simulations of tablet surface density distribution by finite element analysis exhibit excellent agreement with the TPI measured SRI maps. These results show that TPI has an advantage over traditional diametral compression and is more suitable for nondestructive hardness and density distribution monitoring and control of pharmaceutical manufacturing processes.

  • Item type:Article
    ID code:51846
    Dates:
    Date
    Event
    July 2013
    Published
    22 April 2013
    Published Online
    Subjects:Medicine > Pharmacy and materia medica
    Department:UNSPECIFIED
    Depositing user: Pure Administrator
    Date deposited:23 Feb 2015 10:20
    Last modified:11 Nov 2024 10:58
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/51846
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