Lysophosphatidic acid and sphingosine 1-phosphate biology : the role of lipid phosphate phosphatases

Pyne, Susan and Kong, Kok-Choi and Darroch, Peter I (2004) Lysophosphatidic acid and sphingosine 1-phosphate biology : the role of lipid phosphate phosphatases. Seminars in Cell and Developmental Biology, 15 (5). pp. 491-501. ISSN 1084-9521 (https://doi.org/10.1016/j.semcdb.2004.05.007)

Abstract

The biological actions of the lysolipid agonists sphingosine 1-phosphate and lysophosphatidic acid, in addition to other bioactive lipid phosphates such as phosphatidic acid and ceramide 1-phosphate, can be influenced by a family of lipid phosphate phosphatases (LPP), including LPP1, LPP2, LPP3, the Drosophila homologues Wunen (Wun) and Wunen2 (Wun2) and sphingosine 1-phosphate phosphatases 1 and 2 (SPP1, SPP2). This review describes the characteristic of these enzymes and their potential physiological roles in regulating intracellular and extracellular actions and amounts of these lipids in addition to the involvement of these phosphatases in development.

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• Item metadata

  Item type:	Article
  ID code:	49548
  Dates:	Date Event October 2004 Published 1 July 2004 Published Online
  Subjects:	Medicine > Pharmacy and materia medica
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Pure Administrator
  Date deposited:	03 Oct 2014 12:14
  Last modified:	12 Apr 2024 13:55
  URI:	https://strathprints.strath.ac.uk/id/eprint/49548