Proteinase-activated receptors (PARs)

Cunningham, Margaret Rose and Plevin, Robin; Offermanns, Stefan and Rosenthal, Walter, eds. (2008) Proteinase-activated receptors (PARs). In: Encyclopedia of Molecular Pharmacology. Springer, Berlin, pp. 1019-1023. ISBN 9783540389163 (https://doi.org/10.1007/978-3-540-38918-7_122)

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Abstract

Proteinase-activated receptors (PARs) are a unique family of G-protein-coupled receptors (GPCRs) that are activated in response to serine proteinases. There are four PAR family members; PAR-1 through to PAR-4. PAR-1 and PAR-3 respond to thrombin, PAR-2 responds to trypsin, whilst PAR-4 is sensitive to both thrombin- and trypsin-related proteinases.

ORCID iDs

Cunningham, Margaret Rose ORCID logoORCID: https://orcid.org/0000-0001-6454-8671 and Plevin, Robin ORCID logoORCID: https://orcid.org/0000-0002-7849-1220; Offermanns, Stefan and Rosenthal, Walter