Continuous infusion of vancomycin in neonates

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Patel, Anisa D. and Anand, Dhullipala and Lucas, Carol and Thomson, Alison (2013) Continuous infusion of vancomycin in neonates. Archives of Disease in Childhood, 98 (6). pp. 478-479. ISSN 0003-9888 (https://doi.org/10.1136/archdischild-2012-303197)

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Abstract

A one year, retrospective audit of intermittent vancomycin therapy within the Neonatal Unit at the Royal Hospital for Sick Children, Glasgow, found that only 33% of 984 vancomycin trough levels were within the British National Formulary for children (BNFc) target range of 10–15 mg/l and 25% were <10 mg/l. A detailed, prospective review of 20 courses (15 patients) over one month, while using the same dosing guidelines, highlighted that only 23 of 50 concentration measurements (46%) were within the target range and 20% were <10 mg/l, even though the initial doses used (table 1) were higher than those recommended by the BNFc. Dose adjustments were common and up to 80 mg/kg/day was often required for older infants. Appropriate interpretation of concentration results was compromised …

ORCID iDs

Patel, Anisa D., Anand, Dhullipala, Lucas, Carol and Thomson, Alison ORCID logoORCID: https://orcid.org/0000-0002-2354-6116;
CORE (COnnecting REpositories)