Putrescine bisamides from Aglaia gigantea

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Duong, Tu Ngoc and Edrada, RuAngelie and Ebel, Rainer and Wray, Victor and Frank, Walter and Duong, Anh Tuan and Lin, Wen Han and Proksch, Peter and Edrada-Ebel, Ruangelie (2007) Putrescine bisamides from Aglaia gigantea. Journal of Natural Products, 70 (10). pp. 1640-1643. ISSN 0163-3864 (https://doi.org/10.1021/np070184w)

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Abstract

Phytochemical analysis of the leaves of Aglaia gigantea collected in Vietnam yielded three cinnamoyl putrescine bisamide derivatives, which included the known compound dasyclamide ( 1), as well as two new natural products, gigantamide A ( 2) and grandiamide D ( 3). In this study, the structure of dasyclamide ( 1) was confirmed by X-ray crystallography. The structures of the two new alkaloids, gigantamide A ( 2) and grandiamide D ( 3), were elucidated through extensive 1D and 2D NMR spectroscopy and analysis of their mass spectrometric (ESIMS, HRQTOFMS) data. The absolute configuration of grandiamide D ( 3) was determined via Mosher ester derivatization.

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