Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice

Komai-Koma, M and Brombacher, F and Pushparaj, P N and Arendse, B and McSharry, C and Alexander, J and Chaudhuri, R and McKenzie, A N J and McInnes, I and Liew, F Y and Xu, D and Thompson, N.C (2012) Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice. Allergy, 67 (9). pp. 1118-1126. (https://doi.org/10.1111/j.1398-9995.2012.02859.x)

Abstract

The regulation and function of IgE in healthy individuals and in antigen-naïve animals is not well understood. IL-33 administration increases serum IgE in mice with unknown mechanism. We tested the hypothesis that IL-33 provides an antigen-independent stimulus for IgE production and mast cell degranulation.

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• Item metadata

  Item type:	Article
  ID code:	47932
  Dates:	Date Event September 2012 Published
  Notes:	© 2012 John Wiley & Sons A/S.
  Subjects:	Medicine > Pharmacy and materia medica
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Pure Administrator
  Date deposited:	08 May 2014 11:57
  Last modified:	11 Nov 2024 10:30
  Related URLs:	Scopus publication
  URI:	https://strathprints.strath.ac.uk/id/eprint/47932