Local detection of enzymatic ion generation with polycrystalline silicon interdigitated electrodes and its application to biosensing

de la Rica, Roberto and Baldi, Antonio and Fernández-Sánchez, César (2007) Local detection of enzymatic ion generation with polycrystalline silicon interdigitated electrodes and its application to biosensing. Applied Physics Letters, 90. 074102. ISSN 0003-6951 (https://doi.org/10.1063/1.2472718)

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Abstract

Chips containing polycrystalline silicon interdigitated electrodes are modified with the enzyme urease. The sensors are able to detect changes in the resitivity of the solution near their surface, where the enzymatic reaction generates charged species. The electrodes are also grafted with an antigen and queried with different amounts of urease labeled antibody. The response of the modified electrodes is proportional to the amount of enzyme attached to the surface by the biorecognition event, thus validating the assay for biosensing applications.

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• Item metadata

  Item type:	Article
  ID code:	45756
  Dates:	Date Event 12 February 2007 Published 31 January 2007 Accepted
  Subjects:	Science > Physics
  Department:	Faculty of Science > Physics
  Depositing user:	Pure Administrator
  Date deposited:	08 Nov 2013 09:42
  Last modified:	17 Nov 2024 01:08
  URI:	https://strathprints.strath.ac.uk/id/eprint/45756