Facile DNA immobilization on surfaces through a catecholamine polymer

Ham, H. O. and Liu, Z. Q. and Lau, K. H. A. and Lee, H. and Messersmith, P. B. (2011) Facile DNA immobilization on surfaces through a catecholamine polymer. Angewandte Chemie International Edition, 50 (3). pp. 732-736. ISSN 1433-7851 (https://doi.org/10.1002/anie.201005001)

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Abstract

Simple immersion of noble metals, oxides, semiconductors, and synthetic polymer substrates in a mussel-mimetic catecholamine polymer solution p(DOMA-AEMA) leads to formation of a thin film on the substrate. The resulting coated substrates can bind DNA without further surface treatment. This approach provides a new entrance to DNA microarray fabrication.