Simultaneous SPR and electrochemical sensing of an alkane thiol self-assembled monolayer (SAM) - towards an optical biosensor

Sheridan, A.K. and Ngamukot, P. and Bartlett, P.N. and Wilkinson, J.S.; Culshaw, Brian and Miguel, J and Culshaw, Brian and Miguel, J, eds. (2004) Simultaneous SPR and electrochemical sensing of an alkane thiol self-assembled monolayer (SAM) - towards an optical biosensor. In: Second european workshop on optical fibre sensors. Proceedings of the Society of Photo-optical Instrumentation Engineers (SPIE), 5502 . SPIE, ESP, pp. 271-274. ISBN 0819454346 (https://doi.org/10.1117/12.566559)

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Abstract

We present simultaneous electrochemical and waveguide surface plasmon resonance measurements demonstrating the electrochemically controlled desorption of a thiol monolayer from a gold electrode. Self-assembled thiol layers are used in biosensors to enable the attachment of lipids to the sensor. This work demonstrates the potential for development of the device for biological sensing applications. Simultaneous SPR electrochemical measurements are made during the thiol desorption and these results are discussed and compared to the results of a numerical simulation.