Improved estimates for hydration free energy obtained by the reference interaction site model

Chuev, Gennady N. and Fedorov, Maxim V. and Crain, Jason (2007) Improved estimates for hydration free energy obtained by the reference interaction site model. Chemical Physics Letters, 448 (4-6). pp. 198-202. ISSN 0009-2614 (https://doi.org/10.1016/j.cplett.2007.10.003)

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Abstract

We propose to improve the existing free energy expressions obtained within the framework of the reference interaction site model (RISM) combined with the hypernetted closure. The proposed expression is based on the partial wave expression [S. Ten-no, J. Chem. Phys. 115 (2001) 3724] but includes semiempirical corrections to account properly for excluded volume and hydrogen bonding effects. Testing several free energy expressions for various polar and hydrophobic solutes, we have found that such empirical parameterization of the partial wave expression can provide accurate estimates of hydration energies for different hydrophobic and polar solutes. The proposed correction allows one to reduce the discrepancy between the experimental and the calculated data down to 0.7 kcal/mol. (C) 2007 Elsevier B.V. All rights. reserved.

  • Item type:Article
    ID code:35657
    Dates:
    Date
    Event
    14 November 2007
    Published
    Subjects:Science > Physics
    Department:Faculty of Science > Physics
    Depositing user: Pure Administrator
    Date deposited:08 Nov 2011 11:44
    Last modified:08 Apr 2024 19:40
    URI:https://strathprints.strath.ac.uk/id/eprint/35657
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