Synthesis and application of a carbamazepine imprinted polymer for solid-phase extraction from urine and waste water

Beltran, A. and Caro, E. and Marcé, R.M. and Cormack, P.A.G. and Sherrington, D.C. and Borrull, F. (2007) Synthesis and application of a carbamazepine imprinted polymer for solid-phase extraction from urine and waste water. Analytica Chimica Acta, 597 (1). pp. 6-11. ISSN 0003-2670 (https://doi.org/10.1016/j.aca.2007.06.040)

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Abstract

A molecularly imprinted polymer (MIP) designed to enable the selective extraction of carbamazepine (CBZ) from effluent wastewater and urine samples has been synthesised using a non-covalent molecular imprinting approach. The MIP was evaluated chromatographically in the first instance and its affinity for CBZ also confirmed by solid-phase extraction (SPE). The optimal conditions for SPE consisted of conditioning of the cartridge using acidified water purified from a Milli-Q system, loading of the sample under basic aqueous conditions, clean-up using acetonitrile and elution with methanol. The attractive molecular recognition properties of the MIP gave rise to good CBZ recoveries (80%) when 100 mL of effluent water spiked with 1 μg L−1 was percolated through the polymer. For urine samples, 2 mL samples spiked with 2.5 μg L−1 CBZ were extracted with a recovery of 65%. For urine, the linear range was 0.05–24 mg L−1, the limit of detection was 25 μg L−1 and precision, expressed as relative standard deviation at 0.5 mg L−1 (n = 3), was 3.1% and 12.6% for repeatability and reproducibility between days, respectively.

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