Fmoc hydrogels from aromatic carbohydrate amphiphiles

Edwards, A.A. and Birchall, L.S. and Jayawarna, V. and Roy, S. and Hughes, M. and Tuttle, T. and Saudi, N. and Okorogheye, G. and Ulijn, R.V. (2010) Fmoc hydrogels from aromatic carbohydrate amphiphiles. Journal of Pharmacy and Pharmacology, 62 (10). p. 1331. ISSN 0022-3573 (https://doi.org/10.1111/j.2042-7158.2010.01178.x)

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Abstract

Numerous low molecular weight (LMW) hydrogels have been reported but only a small number of these are carbohydrate based. 1—3 LMW gelators are typically amphiphilic molecules where the alignment of hydrophobic and hydrophilic regions facilitates gel formation. Most carbohydrate based LMW gelators form organogels and the hydrophobic element is commonly introduced by modification of a sugar hydroxyl group1,2 although there are a few exceptions. 4 Shinkai et al have also demonstrated that the chiral diversity inherent in a monosaccharide can be used to manipulate gelation properties e.g. organogelation and/or hydrogelation.5 Aromatic carbohydrate amphiphiles, based on galactosamine and glucosamine, were therefore prepared to assess the effect of different aromatic groups and the manipulation of chirality on gelation. The primary goal of this work is to develop galactose-based hydrogels for 3D cell culture of hepatocytes.

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