Optimisation of the enantioselective synthesis of cyanohydrin esters

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Veum, L. and Kanerva, L.T. and Halling, P.J. and Maschmeyer, T. and Hanefeld, U. (2005) Optimisation of the enantioselective synthesis of cyanohydrin esters. Advanced Synthesis and Catalysis, 347 (7-8). pp. 1015-1021. ISSN 1615-4150 (http://dx.doi.org/10.1002/adsc.200505031)

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Abstract

The base- and lipase-catalysed enantioselective synthesis of cyanohydrin esters was investigated, and the problem of previously reported low yields due to residual water in the reaction mixture was addressed. When the lipase was immobilised on Celite R-633 as a carrier, both the enantioselectivity and the reaction times for this dynamic kinetic resolution were improved, thus enabling a highly enantioselective synthesis of aromatic and heteroaromatic cyanohydrin acetates.

ORCID iDs

Veum, L., Kanerva, L.T., Halling, P.J. ORCID logoORCID: https://orcid.org/0000-0001-5077-4088, Maschmeyer, T. and Hanefeld, U.;
  • Item type:Article
    ID code:329
    Dates:
    Date
    Event
    2005
    Published
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user:Users 16 not found.
    Date deposited:13 Mar 2006
    Last modified:11 Nov 2024 08:30
    URI:https://strathprints.strath.ac.uk/id/eprint/329
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