PHYS 329-Applications of ultrafast 2-D infrared spectroscopy to studies of the Fe-hydrogenase enzyme system

Stewart, A. Ian and Towrie, M. and Clark, Ian P. and Parker, Anthony W. and Ibrahim, Saad and Pickett, Chris J. and Hunt, Neil T. (2008) PHYS 329-Applications of ultrafast 2-D infrared spectroscopy to studies of the Fe-hydrogenase enzyme system. Abstracts of papers - American Chemical Society, 235. -. ISSN 0065-7727

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Abstract

Ultrafast two dimensional infrared spectroscopy has been applied to study the structure and vibrational dynamics of model compounds of the active site of the Fe-hydrogenase enzyme system. 1 Studies of these model systems, which allow separation of the active site of the enzyme from the protein scaffolding allow, by comparison of 2D-IR spectra with density functional theory calculations, determination of the solution phase structure of these species. In addition, vibrational coupling and rapid (<5ps), solvent-mediated equilibration of energy between vibrationally-excited states of the carbonyl ligands of the di-iron-based active site is observed prior to relaxation to the ground state. These dynamics are shown to be solvent-dependent and form a basis for determination of the vibrational interactions between active site and protein. The results of two-colour 2D-IR and 2D-IR studies of transient products of a photo-substitution reaction are also presented, which give new insights into vibrational energy relaxation mechanisms in similar, solution-phase metal-carbonyl systems.

ORCID iDs

Stewart, A. Ian, Towrie, M., Clark, Ian P., Parker, Anthony W., Ibrahim, Saad, Pickett, Chris J. and Hunt, Neil T. ORCID logoORCID: https://orcid.org/0000-0001-7400-5152;
CORE (COnnecting REpositories)