Modelling drug-eluting stents

McGinty, Sean and Mckee, Sean and Wadsworth, Roger and McCormick, Christopher (2010) Modelling drug-eluting stents. Mathematical Medicine and Biology, 28 (1). pp. 1-29. ISSN 0265-0746 (https://doi.org/10.1093/imammb/dqq003)

Abstract

In this study, we consider a family of mathematical models to describe the elution of drug from polymer-coated stents into the arterial wall. Our models include the polymer layer, the media, the adventitia, a possible topcoat polymer layer and atherosclerotic plaque. We investigate the relative importance of transmural convection, diffusion and drug-dependent parameters in drug delivery and deposition. Furthermore, we investigate how the release rate from the stent can be altered and examine the resulting effect on cellular drug concentrations.

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• Item metadata

  Item type:	Article
  ID code:	26084
  Dates:	Date Event 22 April 2010 Published
  Subjects:	Science > Mathematics > Probabilities. Mathematical statistics Medicine > Therapeutics. Pharmacology
  Department:	Faculty of Science > Mathematics and Statistics Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Faculty of Engineering > Bioengineering
  Depositing user:	Strathprints Administrator
  Date deposited:	20 Sep 2010 10:28
  Last modified:	11 Nov 2024 09:37
  Related URLs:	Scopus publication http://imammb.oxfordjournals.org/content...
  URI:	https://strathprints.strath.ac.uk/id/eprint/26084