Disrupted-in-Schizophrenia-1

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Muir, W.J. and Pickard, B.S. and Blackwood, D.H.R. (2008) Disrupted-in-Schizophrenia-1. Current Psychiatry Reports, 10 (2). pp. 140-147. ISSN 1523-3812 (https://doi.org/10.1007/s11920-008-0025-2)

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Abstract

Chromosomal abnormalities can be powerful tools to identify genes that influence disease risk. The study of a chromosome translocation that segregated with severe psychiatric illness in a large family led directly to the discovery of a gene disrupted by a chromosomal breakpoint. Disrupted-in-Schizophrenia-1 (DISC1) is now an important candidate risk gene for schizophrenia and affective disorders. We review the work that led up to this discovery and the evidence that it is important in the wider population with schizophrenia and affective disorders. We also discuss the latest findings on the neuronal functions of the protein DISC1 encoded by the gene.

ORCID iDs

Muir, W.J., Pickard, B.S. ORCID logoORCID: https://orcid.org/0000-0002-2374-6329 and Blackwood, D.H.R.;
  • Item type:Article
    ID code:25911
    Dates:
    Date
    Event
    April 2008
    Published
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    Subjects:Medicine > Other systems of medicine
    Medicine > Pharmacy and materia medica
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Strathprints Administrator
    Date deposited:20 Aug 2010 10:44
    Last modified:11 Nov 2024 09:31
    URI:https://strathprints.strath.ac.uk/id/eprint/25911
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