Nanoparticle-enhanced diffraction gratings for ultrasensitive surface plasmon biosensing

Wark, A.W. and Lee, Hye Jin and Qavi, A.J. and Corn, R.M. (2007) Nanoparticle-enhanced diffraction gratings for ultrasensitive surface plasmon biosensing. Analytical Chemistry, 79 (17). pp. 6697-6701. ISSN 0003-2700

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Abstract

Ultrasensitive surface bioaffinity sensors are created by the adsorption of gold nanoparticles onto gold diffraction gratings. An enhanced diffraction obtained in a surface plasmon resonance geometry is observed due to the optical coupling of the planar surface plasmons in the grating to the localized surface plasmons in the gold nanoparticles. As a first example, these nanoparticle grating biosensors are employed to detect unmodified DNA at a concentration of 10 fM.