Modulation of pulmonary vascular tone by novel analogues of tetrahydrobiopterin

Tools

Suckling, C.J. and Kununthur, S.R. and Gibson, C.L. and Wadsworth, R.M. (2005) Modulation of pulmonary vascular tone by novel analogues of tetrahydrobiopterin. Pteridines, 16 (112). ISSN 0933-4807

Full text not available in this repository.Request a copy

Abstract

Tetrahydrobiopterin (BH4), an essential cofactor for nitric oxide synthase (NOS), is a highly polar and unstable molecule, which is subject to autooxidation, which ultimately leads to superoxide production. Novel analogues of BH4, 6-hydroxymethylpterin (HMP) and 6-acetyl-7-dimethyldihydropterin (ADDP), which are radical intermediates having more stable oxidation states, were synthesized. To determine the potential use of the analogues as vasodilatory agents in reducing pulmonary hypertension, we studied their effects on normal pulmonary arteries as well as in pulmonary arteries depleted of endogenous reserves of BH4.

ORCID iDs

Suckling, C.J., Kununthur, S.R., Gibson, C.L. ORCID logoORCID: https://orcid.org/0000-0003-4948-1266 and Wadsworth, R.M.;
CORE (COnnecting REpositories)