Calibration free approaches for rapid polymorph discrimination via low frequency (THz) Raman spectroscopy

Tools

Chong, Magdalene W. S. and Ward, Martin R. and McFarlan, Catriona and Parrott, Andrew J. and Dallin, Paul and Andrews, John and Oswald, Iain D. H. and Nordon, Alison (2024) Calibration free approaches for rapid polymorph discrimination via low frequency (THz) Raman spectroscopy. Chemical Communications. ISSN 1359-7345 (https://doi.org/10.1039/D4CC05591H)

[thumbnail of Chong-etal-CC-2024-Calibration-free-approaches-for-rapid-polymorph-discrimination]
Preview
 Text. Filename: Chong-etal-CC-2024-Calibration-free-approaches-for-rapid-polymorph-discrimination.pdf
Final Published Version
License: Creative Commons Attribution 3.0 logo
Download (901kB)| Preview

Abstract

Application of multivariate curve resolution to non-invasive Raman spectra has been investigated for rapid on-line analysis of crystallisation processes and high-throughput screening. Exploring quantification of mefenamic acid solid forms (form I, form II, and dimethylformamide solvate) from the Raman spectra indicated excellent agreement with off-line X-ray analysis.

ORCID iDs

Chong, Magdalene W. S., Ward, Martin R. ORCID logoORCID: https://orcid.org/0000-0003-0013-5004, McFarlan, Catriona ORCID logoORCID: https://orcid.org/0000-0003-1571-7533, Parrott, Andrew J. ORCID logoORCID: https://orcid.org/0000-0002-4598-2736, Dallin, Paul, Andrews, John, Oswald, Iain D. H. ORCID logoORCID: https://orcid.org/0000-0003-4339-9392 and Nordon, Alison ORCID logoORCID: https://orcid.org/0000-0001-6553-8993;
CORE (COnnecting REpositories)