The Natural Products Atlas 3.0 : extending the database of microbially derived natural products

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Poynton, Ella F and van Santen, Jeffrey A and Pin, Matthew and Contreras, Marla Macias and McMann, Emily and Parra, Jonathan and Showalter, Brandon and Zaroubi, Liana and Duncan, Katherine R and Linington, Roger G (2024) The Natural Products Atlas 3.0 : extending the database of microbially derived natural products. Nucleic Acids Research. gkae1093. ISSN 1362-4962 (https://doi.org/10.1093/nar/gkae1093)

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Abstract

The Natural Products Atlas is a database of microbially derived natural products that contains structures, producing organism taxonomy, biosynthetic and chemical ontology classifications, grouping by compound classes and cross-links to a suite of other natural product-related data resources. The database is supported by a web server that includes functionality to browse the collection, search the database using both chemical structures and text/numerical terms and visualize the chemical diversity it contains using interactive dashboards. In the current database release, we have curated 1347 papers, increasing the number of compounds to 36 545. In addition, we have initiated a large-scale effort to incorporate data from papers reporting structural reassignments and revisions to previously published structures. This effort led to the incorporation of 590 corrections to existing entries, significantly improving the accuracy of the dataset. The Natural Products Atlas may be accessed at www.npatlas.org.

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