Spatial and temporal visualization of polymorphic transformations in pharmaceutical tablets
Gasol-Cardona, Julia and Ward, Martin R. and Gutowski, Olof and Drnec, Jakub and Jandl, Christian and Stam, Danny and Maloney, Andrew G. P. and Markl, Daniel and Price, Stephen W. T. and Oswald, Iain D. H. (2024) Spatial and temporal visualization of polymorphic transformations in pharmaceutical tablets. Angewandte Chemie International Edition. ISSN 1521-3773 (https://doi.org/10.1002/anie.202412976)
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Abstract
X-ray Diffraction Computed Tomography (XRD-CT) represents a cutting-edge method for non-destructive material analysis, offering the unique capability of providing molecular-level information with spatial resolution. In this study, we have applied XRD-CT to investigate pharmaceutically relevant tablets that have been subjected to a range of compression pressures typical in tablet manufacturing. By employing XRD-CT to pharmaceutical tablets, we reveal material changes without tablet destruction, thereby avoiding potential phase transformations during sample preparation that could lead to errors in the interpretation of the processes that have occurred. Utilizing a pressure-sensitive marker, glycolide, we have tracked changes within tablet structures induced by compression, pinpointing locations where glycolide undergoes pressure-induced transformation. Additionally, we conducted a follow-up study with analysis one month later, observing an in-situ hydrolysis reaction of glycolide within the tablets. Through the complementary use of electron diffraction, we have elucidated the structure of the hydrolysis product, further enhancing our understanding of temporal changes in the tablets.
ORCID iDs
Gasol-Cardona, Julia ORCID: https://orcid.org/0009-0006-1249-3609, Ward, Martin R. ORCID: https://orcid.org/0000-0003-0013-5004, Gutowski, Olof, Drnec, Jakub, Jandl, Christian, Stam, Danny, Maloney, Andrew G. P., Markl, Daniel ORCID: https://orcid.org/0000-0003-0411-733X, Price, Stephen W. T. and Oswald, Iain D. H. ORCID: https://orcid.org/0000-0003-4339-9392;-
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Item type: Article ID code: 91222 Dates: DateEvent15 November 2024Published15 November 2024Published Online15 November 2024AcceptedSubjects: Medicine > Pharmacy and materia medica > Pharmaceutical chemistry Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)Depositing user: Pure Administrator Date deposited: 20 Nov 2024 16:36 Last modified: 16 Dec 2024 09:59 URI: https://strathprints.strath.ac.uk/id/eprint/91222