Artificial intelligence (AI) applications in drug discovery and drug delivery : revolutionizing personalized medicine

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Serrano, Dolores R. and Luciano, Francis C. and Anaya, Bryan J. and Ongoren, Baris and Kara, Aytug and Molina, Gracia and Ramirez, Bianca I. and Sánchez-Guirales, Sergio A. and Simon, Jesus A. and Tomietto, Greta and Rapti, Chrysi and Ruiz, Helga K. and Rawat, Satyavati and Kumar, Dinesh and Lalatsa, Aikaterini (2024) Artificial intelligence (AI) applications in drug discovery and drug delivery : revolutionizing personalized medicine. Pharmaceutics, 16 (10). 1328. ISSN 1999-4923 (https://doi.org/10.3390/pharmaceutics16101328)

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Abstract

Artificial intelligence (AI) encompasses a broad spectrum of techniques that have been utilized by pharmaceutical companies for decades, including machine learning, deep learning, and other advanced computational methods. These innovations have unlocked unprecedented opportunities for the acceleration of drug discovery and delivery, the optimization of treatment regimens, and the improvement of patient outcomes. AI is swiftly transforming the pharmaceutical industry, revolutionizing everything from drug development and discovery to personalized medicine, including target identification and validation, selection of excipients, prediction of the synthetic route, supply chain optimization, monitoring during continuous manufacturing processes, or predictive maintenance, among others. While the integration of AI promises to enhance efficiency, reduce costs, and improve both medicines and patient health, it also raises important questions from a regulatory point of view. In this review article, we will present a comprehensive overview of AI’s applications in the pharmaceutical industry, covering areas such as drug discovery, target optimization, personalized medicine, drug safety, and more. By analyzing current research trends and case studies, we aim to shed light on AI’s transformative impact on the pharmaceutical industry and its broader implications for healthcare.

ORCID iDs

Serrano, Dolores R., Luciano, Francis C., Anaya, Bryan J., Ongoren, Baris, Kara, Aytug, Molina, Gracia, Ramirez, Bianca I., Sánchez-Guirales, Sergio A., Simon, Jesus A., Tomietto, Greta, Rapti, Chrysi, Ruiz, Helga K., Rawat, Satyavati, Kumar, Dinesh and Lalatsa, Aikaterini ORCID logoORCID: https://orcid.org/0000-0003-4791-7468;
CORE (COnnecting REpositories)