A continuous micro-feeder for cohesive pharmaceutical materials

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Hou, P. and Besenhard, M.O. and Halbert, G. and Naftaly, M. and Markl, D. (2024) A continuous micro-feeder for cohesive pharmaceutical materials. International Journal of Pharmaceutics, 662. 124528. ISSN 1873-3476 (https://doi.org/10.1016/j.ijpharm.2024.124528)

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Abstract

Over the past decade, continuous manufacturing has garnered significant attention in the pharmaceutical industry. Still, numerous continuous unit operations need developments, such as powder blending and feeding at low and high throughputs. Especially the continuous and consistent feeding of solid drug substances and excipients at low feed rates remains challenging. This study demonstrates a micro-feeder capable of feeding poorly-flowing pharmaceutical powders at low feed rates. The system performance was investigated using three grades of pharmaceutical powder: croscarmellose sodium (cohesive), magnesium stearate (very cohesive), and an active ingredient, paracetamol (non-flowing). The results show that the micro-feeder can continuously and consistently feed powders at low flow rates (<20 g/h) with low variability (<10 % for non-flowing materials and < 5 % for cohesive materials). Notably, the micro-feeder achieves these results without any feedback control and remains unaffected by refilling, making it a truly versatile and industry-relevant solution. The study’s results demonstrate that this micro-feeder system effectively tackles the challenge of consistent and accurate powder feeding at low rates.

ORCID iDs

Hou, P. ORCID logoORCID: https://orcid.org/0000-0001-5166-8869, Besenhard, M.O., Halbert, G., Naftaly, M. and Markl, D. ORCID logoORCID: https://orcid.org/0000-0003-0411-733X;
CORE (COnnecting REpositories)