Campylobacter jejuni is not merely a commensal in commercial broiler chickens and affects bird welfare

Humphrey, Suzanne and Chaloner, Gemma and Kemmett, Kirsty and Davidson, Nicola and Williams, Nicola and Kipar, Anja and Humphrey, Tom and Wigley, Paul (2014) Campylobacter jejuni is not merely a commensal in commercial broiler chickens and affects bird welfare. mBio, 5 (4). e01364-14. ISSN 2161-2129 (https://doi.org/10.1128/mBio.01364-14)

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Abstract

Campylobacter jejuni is the leading cause of bacterial food-borne infection; chicken meat is its main source. C. jejuni is considered commensal in chickens based on experimental models unrepresentative of commercial production. Here we show that the paradigm of Campylobacter commensalism in the chicken is flawed. Through experimental infection of four commercial breeds of broiler chickens, we show that breed has a significant effect on C. jejuni infection and the immune response of the animals, although these factors have limited impact on the number of bacteria in chicken ceca. All breeds mounted an innate immune response. In some breeds, this response declined when interleukin-10 was expressed, consistent with regulation of the intestinal inflammatory response, and these birds remained healthy. In another breed, there was a prolonged inflammatory response, evidence of damage to gut mucosa, and diarrhea. We show that bird type has a major impact on infection biology of C. jejuni. In some breeds, infection leads to disease, and the bacterium cannot be considered a harmless commensal. These findings have implications for the welfare of chickens in commercial production where C. jejuni infection is a persistent problem.

ORCID iDs

Humphrey, Suzanne ORCID logoORCID: https://orcid.org/0000-0002-9893-3209, Chaloner, Gemma, Kemmett, Kirsty, Davidson, Nicola, Williams, Nicola, Kipar, Anja, Humphrey, Tom and Wigley, Paul;
CORE (COnnecting REpositories)