Directing hydrogen isotope exchange with aryl carboxylic acids

Mudd, Richard J. and Reid, Marc and Paterson, Laura C. and Atzrodt, Jens and Derdau, Volker and Kerr, William J. (2024) Directing hydrogen isotope exchange with aryl carboxylic acids. Synlett. ISSN 0936-5214 (https://doi.org/10.1055/a-2239-6965)

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Abstract

A highly effective and selective ortho-directed hydrogen isotope exchange process for aryl carboxylic acids has been achieved by using an iridium(I) N-heterocyclic carbene/phosphine complex under mild and neutral conditions. Good levels of deuterium incorporation have been delivered across a wide array of examples, including a number of biologically active drug compounds.

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• Item metadata

  Item type:	Article
  ID code:	87924
  Dates:	Date Event 5 February 2024 Published 5 February 2024 Published Online 5 January 2024 Accepted 24 November 2023 Submitted
  Notes:	Publisher Copyright: © 2023 Georg Thieme Verlag. All rights reserved.
  Subjects:	Science > Chemistry
  Department:	University of Strathclyde > University of Strathclyde
  Depositing user:	Pure Administrator
  Date deposited:	26 Jan 2024 11:59
  Last modified:	09 Apr 2024 04:30
  URI:	https://strathprints.strath.ac.uk/id/eprint/87924