Ethnic inequalities in positive SARS-CoV-2 tests, infection prognosis, COVID-19 hospitalisations, and deaths : analysis of 2 years of a record linked national cohort study in Scotland

Amele, Sarah and Kibuchi, Eliud and McCabe, Ronan and Pearce, Anna and Henery, Paul and Hainey, Kirsten and Fagbamigbe, Adeniyi Francis and Kurdi, Amanj and McCowan, Colin and Simpson, Colin R and Dibben, Chris and Buchanan, Duncan and Demou, Evangelia and Almaghrabi, Fatima and Anghelescu, Gina and Taylor, Harry and Tibble, Holly and Rudan, Igor and Nazroo, James and Becares, Laia and Daines, Luke and Irizar, Patricia and Jayacodi, Sandra and Pattaro, Serena and Sheikh, Aziz and Katikireddi, Srinivasa Vittal (2023) Ethnic inequalities in positive SARS-CoV-2 tests, infection prognosis, COVID-19 hospitalisations, and deaths : analysis of 2 years of a record linked national cohort study in Scotland. Journal of Epidemiology and Community Health, 77 (10). pp. 641-648. ISSN 0143-005X (https://doi.org/10.1136/jech-2023-220501)

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Abstract

Background: This study aims to estimate ethnic inequalities in risk for positive SARS-CoV-2 tests, COVID-19 hospitalisations and deaths over time in Scotland. Methods: We conducted a population-based cohort study where the 2011 Scottish Census was linked to health records. We included all individuals≥16 years living in Scotland on 1 March 2020. The study period was from 1 March 2020 to 17 April 2022. Self-reported ethnic group was taken from the census and Cox proportional hazard models estimated HRs for positive SARS-CoV-2 tests, hospitalisations and deaths, adjusted for age, sex and health board. We also conducted separate analyses for each of the four waves of COVID-19 to assess changes in risk over time. Findings: Of the 4 358 339 individuals analysed, 1 093 234 positive SARS-CoV-2 tests, 37 437 hospitalisations and 14 158 deaths occurred. The risk of COVID-19 hospitalisation or death among ethnic minority groups was often higher for White Gypsy/Traveller (HR 2.21, 95% CI (1.61 to 3.06)) and Pakistani 2.09 (1.90 to 2.29) groups compared with the white Scottish group. The risk of COVID-19 hospitalisation or death following confirmed positive SARS-CoV-2 test was particularly higher for White Gypsy/Traveller 2.55 (1.81–3.58), Pakistani 1.75 (1.59–1.73) and African 1.61 (1.28–2.03) individuals relative to white Scottish individuals. However, the risk of COVID-19-related death following hospitalisation did not differ. The risk of COVID-19 outcomes for ethnic minority groups was higher in the first three waves compared with the fourth wave. Interpretation: Most ethnic minority groups were at increased risk of adverse COVID-19 outcomes in Scotland, especially White Gypsy/Traveller and Pakistani groups. Ethnic inequalities persisted following community infection but not following hospitalisation, suggesting differences in hospital treatment did not substantially contribute to ethnic inequalities.

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