Challenges of using protein antibiotics for pathogen control

Chai, Ray and Rooney, William M and Milner, Joel J and Walker, Daniel (2021) Challenges of using protein antibiotics for pathogen control. Pest Management Science, 77 (9). pp. 3836-3840. ISSN 1526-498X (https://doi.org/10.1002/ps.6312)

[thumbnail of Chai-etal-PMS2021-Challenges-using-protein-antibiotics-pathogen-control]
Preview
Text. Filename: Chai_etal_PMS2021_Challenges_using_protein_antibiotics_pathogen_control.pdf
Final Published Version
License: Creative Commons Attribution 4.0 logo

Download (257kB)| Preview

Abstract

Bacterial phytopathogens represent a significant threat to many economically important crops. Current control measures often inflict harm on the environment and may ultimately impact on human health through the spread of antibiotic resistance. Antimicrobial proteins such as bacteriocins have been suggested as the next generation of disease control agents since they are able to specifically target the pathogen of interest with minimal impact on the wider microbial community and environment. However, substantial gaps in knowledge with regards to the efficacy and application of bacteriocins to combat phytopathogenic bacteria remain. Here we highlight the immediate challenges the community must address to ensure maximum exploitation of antimicrobial proteins in the field.