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The interaction of bisphosphonate-coated hydroxyapatite and osteoblasts

Ganguli, A. and Lloyd, A.W. and Meikle, S.T. and Grant, M.H. (2001) The interaction of bisphosphonate-coated hydroxyapatite and osteoblasts. In: Transactions of the 25th Annual Meeting of the Society for Biomaterials. Society for Biomaterials. ISBN 8024572001

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Abstract

Coating of the hydroxyapatite (HA) ceramic component of artificial hip joints with the bisphosphonates clodronate (C) and pamidronate (P) has been proposed as a means to minimise osteolysis and thereby prevent loosening of the implant. However, the effect of the bisphosphonate coating on bacterial adhesion to the HA materials must be determined before this approach can be implemented.