Identifying the operating space and repeatability of a novel filament free FDM printer

Prasad, Elke and Robertson, John and Halbert, Gavin W. (2022) Identifying the operating space and repeatability of a novel filament free FDM printer. In: AAPS 2022 Pharm Sci 360, 2022-10-16 - 2022-10-19, USA.

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Abstract

Purpose -- Processing solid dispersion filament feedstock materials by Fused Deposition Modelling (FDM) have shown to facilitate control of drug release profiles through micro-structure design. The mechanical and rheological properties of many feedstock materials, particularly immediate release polymers, are not suitable for processing in a conventional FDM 3D printer. This study shows the operational space and performance of a novel non-filament based FDM printer, overcoming these material-based limitations. Conclusions -- Operational limits, in terms of rheological properties of formulations, have been identified for this novel non-filament FDM printer. Repeatability of tablet prints showed good uniformity of mass, complying with pharmacopeial specifications for oral solid dose forms.

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