Identifying the operating space and repeatability of a novel filament free FDM printer

Prasad, Elke and Robertson, John and Halbert, Gavin W. (2022) Identifying the operating space and repeatability of a novel filament free FDM printer. In: AAPS 2022 Pharm Sci 360, 2022-10-16 - 2022-10-19, USA.

[thumbnail of Prasad-etal-AAPS-2022-Identifying-the-operating-space-and-repeatability-of-a-novel-filament-free-FDM-printer]
Preview
 Text. Filename: Prasad_etal_AAPS_2022_Identifying_the_operating_space_and_repeatability_of_a_novel_filament_free_FDM_printer.pdf
Final Published Version
License: Creative Commons Attribution 4.0 logo
Download (701kB)| Preview

Abstract

Purpose -- Processing solid dispersion filament feedstock materials by Fused Deposition Modelling (FDM) have shown to facilitate control of drug release profiles through micro-structure design. The mechanical and rheological properties of many feedstock materials, particularly immediate release polymers, are not suitable for processing in a conventional FDM 3D printer. This study shows the operational space and performance of a novel non-filament based FDM printer, overcoming these material-based limitations. Conclusions -- Operational limits, in terms of rheological properties of formulations, have been identified for this novel non-filament FDM printer. Repeatability of tablet prints showed good uniformity of mass, complying with pharmacopeial specifications for oral solid dose forms.

ORCID iDs

Prasad, Elke ORCID logoORCID: https://orcid.org/0000-0002-5412-9374, Robertson, John ORCID logoORCID: https://orcid.org/0000-0002-2191-1319 and Halbert, Gavin W.;
CORE (COnnecting REpositories)