Anxiolytic, antidepressant and antioxidant activity of the methanol extract of Canarium resiniferum leaves
Shah, Md Shahin and Tayab, Mohammed Abu and Rahman, Anisur and Hasan, Muhammad Nazmul and Talukder, Md Saddam Hossain and Uddin, A.M. Kafil and Jabed, Md and Chy, Md Nazim Uddin and Paul, Arkajyoti and Rahman, Md Masudur and Bin Emran, Talha and Seidel, Veronique (2022) Anxiolytic, antidepressant and antioxidant activity of the methanol extract of Canarium resiniferum leaves. Journal of Traditional and Complementary Medicine, 12 (6). pp. 567-574. ISSN 2225-4110 (https://doi.org/10.1016/j.jtcme.2022.07.001)
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Abstract
Background and aim This study evaluated the anxiolytic, antidepressant, and antioxidant activity of the methanol extract of Canarium resiniferum (MECR) leaves, and determined the total phenolic and flavonoid contents in this extract. Experimental procedure The anxiolytic effect of MECR (100, 200, 400 mg/kg, p.o.) was tested in mice using the elevated plus-maze (EPM) test, the hole-board test (HBT), and the light-dark box (LDB) test. Its antidepressant effect was evaluated in the tail suspension (TST) and the forced swim (FST) tests. The total phenolic (TPC) and flavonoid (TFC) content was measured using standard colorimetric assays. Antioxidant activity was determined using the DPPH radical scavenging and ferric reducing antioxidant power (FRAP) assays. Results and conclusion MECR, at all doses, showed dose-dependent anxiolytic activity. At 400 mg/kg, it significantly increased the time spent and number of entries in the open arms (EPM test), the number of head-dips (HBT), and the time spent into the light compartment (LDB) test compared to the control. In the TST and FST, MECR dose-dependently reduced the duration of immobility compared to untreated animals. This was significant for all doses except for 100 mg/kg in the FST model. MECR showed high TPC and TFC (90.94 ± 0.75 mg GAE/g and 51.54 ± 0.78 mg QE/g of dried extract, respectively) and displayed potent activity in the DPPH radical scavenging (IC50 = 177.82 μg/mL) and FRAP assays. These findings indicate that C. resiniferum has the potential to alleviate anxiety and depression disorders, which merits further exploration.
ORCID iDs
Shah, Md Shahin, Tayab, Mohammed Abu, Rahman, Anisur, Hasan, Muhammad Nazmul, Talukder, Md Saddam Hossain, Uddin, A.M. Kafil, Jabed, Md, Chy, Md Nazim Uddin, Paul, Arkajyoti, Rahman, Md Masudur, Bin Emran, Talha and Seidel, Veronique ORCID: https://orcid.org/0000-0003-3880-5261;-
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Item type: Article ID code: 81879 Dates: DateEvent1 November 2022Published3 August 2022Published Online28 July 2022AcceptedSubjects: Medicine > Botanic, Thomsonian, and eclectic medicine Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 16 Aug 2022 09:55 Last modified: 17 Dec 2024 21:48 URI: https://strathprints.strath.ac.uk/id/eprint/81879