ActinoBase : tools and protocols for researchers working on Streptomyces and other filamentous actinobacteria

Feeney, Morgan Anne and Newitt, Jake Terry and Addington, Emily and Algora-Gallardo, Lis and Allan, Craig and Balis, Lucas and Birke, Anna S. and Castaño-Espriu, Laia and Charkoudian, Louise K. and Devine, Rebecca and Gayrard, Damien and Hamilton, Jacob and Hennrich, Oliver and Hoskisson, Paul A. and Keith-Baker, Molly and Klein, Joshua G. and Kruasuwan, Worarat and Mark, David R. and Mast, Yvonne and McHugh, Rebecca E. and McLean, Thomas C. and Mohit, Elmira and Munnoch, John T. and Murray, Jordan and Noble, Katie and Otani, Hiroshi and Parra, Jonathan and Pereira, Camila F. and Perry, Louisa and Pintor-Escobar, Linamaria and Pritchard, Leighton and Prudence, Samuel M. M. and Russell, Alicia H. and Schniete, Jana K. and Seipke, Ryan F. and Sélem-Mojica, Nelly and Undabarrena, Agustina and Vind, Kristiina and van Wezel, Gilles P. and Wilkinson, Barrie and Worsley, Sarah F. and Duncan, Katherine R. and Fernández-Martínez, Lorena T. and Hutchings, Matthew I. (2022) ActinoBase : tools and protocols for researchers working on Streptomyces and other filamentous actinobacteria. Microbial Genomics, 8 (7). 000824. ISSN 2057-5858 (

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Actinobacteria is an ancient phylum of Gram-positive bacteria with a characteristic high GC content to their DNA. The ActinoBase Wiki is focused on the filamentous actinobacteria, such as Streptomyces species, and the techniques and growth conditions used to study them. These organisms are studied because of their complex developmental life cycles and diverse specialised metabolism which produces many of the antibiotics currently used in the clinic. ActinoBase is a community effort that provides valuable and freely accessible resources, including protocols and practical information about filamentous actinobacteria. It is aimed at enabling knowledge exchange between members of the international research community working with these fascinating bacteria. Actin-oBase is an anchor platform that underpins worldwide efforts to understand the ecology, biology and metabolic potential of these organisms. There are two key differences that set ActinoBase apart from other Wiki-based platforms: [1] ActinoBase is specifically aimed at researchers working on filamentous actinobacteria and is tailored to help users overcome challenges working with these bacteria and [2] it provides a freely accessible resource with global networking opportunities for researchers with a broad range of experience in this field.