3D-printed high-resolution microchannels for contrast enhanced ultrasound research

Domingo-Roca, Roger and Gilmour, Lauren and Asciak, Lisa and Sarrigiannidis, Stylianos and Dobre, Oana and Salmeron-Sanchez, Manuel and Sandison, Mairi and O'Leary, Richard and Jackson-Camargo, Joseph and Mulvana, Helen; (2022) 3D-printed high-resolution microchannels for contrast enhanced ultrasound research. In: 2021 IEEE International Ultrasonics Symposium (IUS). 2021 IEEE Ultrasonics Symposium (IUS), 2021-Janu . IEEE, CHN, pp. 1-4. ISBN 9781665403559 (https://doi.org/10.1109/ius52206.2021.9763442)

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Abstract

Systemically circulating microbubbles are used as contrast agents to aid both drug targeting and delivery using ultrasound. Exploiting their acoustic behaviour in small diameter vessels is critical for both applications, but the highly controlled experiments required to support this are not possible in vivo and challenging in vitro. Experimental platforms with small diameter channels (below 200 microns) are not readily available nor able to represent vascular geometries, leaving the existence and extent of microbubble-microvessel interactions incompletely defined. In this work we present a 3D-printed microchannel platform using tissue-mimicking hydrogels featuring radii down to 75 microns. We demonstrate application to study microbubble behaviour via acoustic backscatter under controlled environments in physiologically-relevant conditions.

ORCID iDs

Domingo-Roca, Roger ORCID logoORCID: https://orcid.org/0000-0001-6080-0083, Gilmour, Lauren, Asciak, Lisa, Sarrigiannidis, Stylianos, Dobre, Oana, Salmeron-Sanchez, Manuel, Sandison, Mairi ORCID logoORCID: https://orcid.org/0000-0003-1021-1461, O'Leary, Richard ORCID logoORCID: https://orcid.org/0000-0002-4092-2101, Jackson-Camargo, Joseph and Mulvana, Helen ORCID logoORCID: https://orcid.org/0000-0002-5058-0299;